This was the first and only theatrical film directed by Joan Rivers who makes a cameo appearance as a comic nurse, and her daughter Melissa Rivers also has a bit part.[1] Rivers' husband Edgar Rosenberg was producer.[1]

It is also Billy Crystal's first starring role.

There are many cameo appearances by notable performers of the time, including Imogene Coca, Richard Deacon, Norman Fell, Fannie Flagg, Alice Ghostley, Roosevelt Grier, George Gobel, Paul Lynde, Roddy McDowall, Sheree North, Charles Pierce, Tom Poston, Charlotte Rae, Jimmie Walker and Michael Keaton (in his film debut in a bit part).[1]

The hospital where Lionel goes for the delivery is called the Mary Baker Eddy Memorial Hospital. Eddy was the founder of the Christian Science movement, which does not utilize traditional hospitals.

Whereas the similarly plotted Junior (1994) explains how its male protagonist gets pregnant (injection of a fertilized embryo into the abdominal cavity), in Rabbit Test this area is never delved into; Lionel simply has sex (he's on the bottom) and becomes pregnant.

Lionel is a young man who has never had sex and is engaged to be married. His cousin sets him up with a one-night stand, and not long after this he finds himself to be the world's first pregnant man.